Journal of Diabetes Research / 2018 / Article / Tab 1

Review Article

Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment

Table 1

Accumulation of upstream glycolytic intermediates and their consequences.

Glycolytic intermediateAlternative pathwayConsequence

Glyceraldehyde-3-phosphate(1) De novo synthesis of DAGDAG activates protein kinase C resulting in altered intracellular phosphorylation levels
(2) Glycosylation pathwaysGlycation of various intra- and extracellular proteins and lipids
Fructose-6-phosphate(3) Hexosamine pathway
Glucose(4) Polyol pathwayLeads to depletion of intracellular NADPH

leads to formation of advanced glycation end products (AGE). renders the neuron susceptible to oxidation.

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