PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus

Figure 2

PTPN2 expression in PBMCs is downregulated in T2DM and positively correlated with VDR. (a) PTPN2 protein levels determined by Western blot ( in each group, age- and gender-matched); β-actin was used as loading controls. (b) PTPN2 mRNA levels in NC (), normo (), micro (), and macro () groups were quantified by real-time RT-qPCR. Scatterplot showing a positive relationship between PTPN2 mRNA levels and VDR mRNA level (; ; ). (c) Scatterplot showing inverse relationship between PTPN2 mRNA levels and uACR level (; ; ). Data represents mean ± SD versus NC (), versus normo (, ), and versus micro ().

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