PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus
Table 1
Clinical parameters () of study participants.
Subjects
NC
Normo
Micro
Macro
30
29
34
38
Gender, M/F
14/16
16/13
19/15
25/13
Age, y
52.34 ± 16.82
53.92 ± 11.92
51.82 ± 13.53
52.42 ± 18.13
BMI, kg/m2
23.01 ± 3.92
23.73 ± 4.02
24.52 ± 3.89
23.27 ± 3.15
Duration of disease, y
—
6.92 ± 5.79
7.39 ± 6.28
8.11 ± 6.23
SBP, mmHg
123.3 ± 11.7
126.8 ± 12.3
132.8 ± 16.8
148.6 ± 19.2#
DBP, mmHg
72.8 ± 9.7
73.8 ± 11.9
84.2 ± 10.4#
85.9 ± 13.3#
ALB, g/L
46.68 ± 4.98
40.23 ± 5.18
39.43 ± 6.92
38.23 ± 7.90
Hb, g/L
135.8 ± 15.9
138.5 ± 14.8
136.6 ± 15.2
127.3 ± 21.6
TG, mmol/L
2.11 ± 2.09
2.03 ± 1.83
2.21 ± 2.05
2.98 ± 2.82#△
TC, mmol/L
4.37 ± 1.03
4.73 ± 2.85
4.88 ± 2.05
5.07 ± 2.85
FBG, mmol/L
5.03 ± 1.64
8.01 ± 2.66
8.49 ± 2.38
8.20 ± 2.55
HbA1c, %
—
8.49 ± 2.03
8.99 ± 2.58
9.23 ± 1.98
Calcium, mmol/L
2.33 ± 0.19
2.12 ± 0.18
2.11 ± 0.14
2.29 ± 0.12
25(OH)D, ng/mL
21.72 ± 3.92
19.63 ± 3.72
18.76 ± 7.92
14.20 ± 6.86#△
IL-6, pg/mL
47.82 ± 39.77
136.50 ± 129.60
327.39 ± 318.36#
370.39 ± 328.53#
eGFR, mL/min
112.24 ± 12.84
118.63 ± 29.83
113.53 ± 31.84
82.63 ± 23.62#△
uACR, μg/mg
8.98 ± 3.62
13.80 ± 7.35
138.52 ± 96.31#
1263.11 ± 787.77##△△
VDR mRNA in PBMC
1.24 ± 0.62
0.82 ± 0.52
0.62 ± 0.56#
0.39 ± 0.36#△
M: male; F: female; —: no data. Results are expressed as mean ± SD or ratio. Compared with the NC group, ,; compared with the normo group, ,; compared with the micro group, ,.
