Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats
Table 1
Lipid profiles of different groups of rats during the experiment and after the induction of diabetes by streptozotocin. Data was expressed as mean ± standard deviation (SD). Significances among different groups were determined by using the one-way analysis of variance (ANOVA) test. : significance versus control, : significance versus diabetic control.
Rat groups
Cholesterol (mmol/L)
High-density lipoprotein (mmol/L)
Low-density lipoprotein (mmol/L)
Triacylglycerol (mmol/L)
Group 1: nondiabetic control (NC)
1.37 ± 0.13
1.30 ± 0.10
0.23 ± 0.02
0.63 ± 0.13
Group 2: diabetic control (DC)
1.39 ± 0.10
1.11 ± 0.21
0.33 ± 0.03
0.82 ± 0.17
Group 3: diabetic and metformin (DM)
1.47 ± 0.23 ,
1.31 ± 0.19 ,
0.30 ± 0.06 ,
1.98 ± 0.65 ,
Group 4: diabetic and olive oil (DO)
1.42 ± 0.42 ,
1.31 ± 0.22 ,
0.36 ± 0.04 ,
1.15 ± 0.47 ,
Group 5: diabetic, olive oil, and metformin (DOM)
1.36 ± 0.25 ,
1.26 ± 0.09 ,
0.31 ± 0.12 ,
1.42 ± 0.44 ,
Group 6: diabetic and olive oil pretreatment (DOP)
