Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats

Table 2

Liver functions of different groups of rats during the experiment and after the induction of diabetes by streptozotocin. Data was expressed as mean ± standard deviation (SD). Significances among different groups were determined by using the one-way analysis of variance (ANOVA) test. : significance versus control, : significance versus diabetic control.

Rat groups	Aspartate aminotransferase (U/L)	Alanine aminotransferase (U/L)	Alkaline phosphatase (U/L)	Bilirubin (μmol/L)	Total protein (g/L)	Albumin (g/L)
Group 1: nondiabetic control (NC)	114.01 ± 8.27	49.20 ± 11.84	134.20 ± 21.79	2.83 ± 0.41	70.00 ± 2.28	11.17 ± 1.72
Group 2: diabetic control (DC)	127.00 ± 18.83	106.00 ± 14.25	329.25 ± 24.19	2.60 ± 0.89	68.40 ± 2.79	9.60 ± 1.95
Group 3: diabetic and metformin (DM)	153.52 ± 27.24; ,	92.60 ± 18.40; ,	302.00 ± 73.70; ,	3.50 ± 1.22; ,	65.83 ± 3.87; ,	10.50 ± 1.87; ,
Group 4: diabetic and olive oil (DO)	134.00 ± 14.37; ,	91.16 ± 13.05; ,	568.33 ± 110.32; ,	3.33 ± 1.21; ,	75.67 ± 4.89; ,	11.67 ± 1.37; ,
Group 5: diabetic, olive oil and metformin (DOM)	136.67 ± 34.05; ,	96.00 ± 11.47; ,	348.68 ± 94.53; ,	2.83 ± 0.41; ,	72.50 ± 2.17; ,	12.17 ± 0.98; ,
Group 6: diabetic and olive oil pretreatment (DOP)	114.60 ± 15.37; ,	67.64 ± 12.10; ,	226.17 ± 53.05; ,	3.00 ± 1.10; ,	74.17 ± 3.76; ,	11.00 ± 0.63; ,