Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats
Table 3
Kidney functions of different groups of rats during the experiment and after the induction of diabetes by streptozotocin. Data was expressed as mean ± standard deviation (SD). Significances among different groups were determined by using the one-way analysis of variance (ANOVA) test. : significance versus control, : significance versus diabetic control.
Rat groups
Blood urea nitrogen (mmol/L)
Creatinine (μmol/L)
Uric acid (μmol/L)
Group 1: nondiabetic control (NC)
7.23 ± 0.79
42.83 ± 5.38
55.17 ± 7.83
Group 2: diabetic control (DC)
7.84 ± 1.79
49.80 ± 8.90
48.80 ± 4.09
Group 3: diabetic and metformin (DM)
10.25 ± 1.73 ,
47.67 ± 5.54 ,
65.83 ± 11.84 ,
Group 4: diabetic and olive oil (DO)
7.22 ± 2.14 ,
48.67 ± 2.50 ,
49.33 ± 15.32 ,
Group 5: diabetic, olive oil, and metformin (DOM)
7.02 ± 1.48 ,
48.17 ± 5.27 ,
55.67 ± 7.79 ,
Group 6: diabetic and olive oil pretreatment (DOP)
