Changes in Immunoreactivity of Sensory Substances within the Enteric Nervous System of the Porcine Stomach during Experimentally Induced Diabetes
Table 1
SP-, CGRP-, and L-ENK-immunoreactive nerve fibres in various parts of the porcine stomach under physiological conditions (control group) and during experimentally induced diabetes (experimental group).
Stomach part
Control group
Experimental group
Antrum
Corpus
Pylorus
Antrum
Corpus
Pylorus
SP
Circular muscle layer
4.82 ± 0.16
3.65 ± 0.16
6.07 ± 0.13
7.42 ± 0.37
5.63 ± 0.15
10.75 ± 0.4
Submucosal/mucosal layer
2.8 ± 0.28
5.19 ± 0.20
2.41 ± 0.18
6.72 ± 0.16
9.46 ± 0.41
2.89 ± 0.25
CGRP
Circular muscle layer
6.10 ± 0.08
6.20 ± 0.18
6.24 ± 0.33
10.44 ± 0.26
11.38 ± 0.34
8.85 ± 0.19
Submucosal/mucosal layer
2.58 ± 0.12
2.08 ± 0.14
3.40 ± 0.18
2.88 ± 0.18
2.45 ± 0.09
3.14 ± 0.26
L-ENK
Circular muscle layer
1.63 ± 0.21
3.11 ± 0.22
1.78 ± 0.15
1.98 ± 0.12
1.47 ± 0.37
2.10 ± 0.24
Submucosal/mucosal layer
1.81 ± 0.24
1.43 ± 0.09
2.25 ± 0.10
1.62 ± 0.51
1.58 ± 0.11
2.55 ± 0.25
Statistically significant data ( and ). Average number of nerve profiles per area (0.55 μm2) studied (mean ± SEM).
