The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice

Figure 2

Zonation of metabolic enzymes in the kidney from NaW-IRS2-KO mice. The gluconeogenic enzyme PEPCK (a–d) and the glycolytic enzyme PK-M (e–h) were immunodetected in formalin-fixed paraffin-embedded kidneys from untreated WT (WT), treated WT (NaW-WT), untreated IRS2-KO (IRS2-KO), and treated IRS2-KO (NaW-IRS2-KO) mice. (i–l) Magnifications of the renal cortex from (a)–(d), respectively. (m–p) Magnifications of the renal cortex from (e)–(h), respectively. c: cortex; om: outer medulla; im: inner medulla, pt: proximal tubule; npt: nonproximal tubule; g: glomerulus. Representative images of each group.