The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice

Figure 4

NaW-induced ERK1/2 activation in proximal tubules from the IRS2-KO kidney. Activation of ERK1/2 was analyzed in situ by immunodetection of phosphorylated residues Thr202/Tyr204 in formalin-fixed paraffin-embedded kidneys from (a) untreated WT (WT), (b) treated WT (NaW-WT), (c) untreated IRS2-KO (IRS2-KO), and (d) treated IRS2-KO (NaW-IRS2-KO) mice. Asterisks: proximal tubule. Representative images of each group.

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