Integration of Routine Parameters of Glycemic Variability in a Simple Screening Method for Partial Remission in Children with Type 1 Diabetes

Figure 1

Evolution of HbA_1C and C-peptide values at diagnosis and during follow-up. Graphs represent mean HbA_1C levels (in %) in PR (a) and no PR (b) groups, mean C-peptide values (in pmol/mL) in PR (c) and no PR (d) groups at diagnosis, and one and two years postdiagnosis. Mean HbA_1C levels were at 10.6 ± 2.6% in PR and 11.2 ± 3% in no PR group (). Those levels were, respectively, at 6.9% (6.2–7.5) and 7.7% (6.9–8.6) at one year () and at 7.5% (6.7–8.1) and 7.7% (6.9–8.5) at two years (), in patients with PR and without PR. For the remitter group, median C-peptide levels were, respectively, at 0.21 pmol/mL (0.11–0.35), 0.22 pmol/mL (0.1–0.41), and 0.11 pmol/mL (0–0.28) at diagnosis, one year and two years postdiagnosis. For the nonremitter group, median C-peptide levels were, respectively, at 0.15 pmol/mL (0.1–0.23), 0.05 pmol/mL (0–0.17), and 0 pmol/mL (0–0.09) at diagnosis, one year and two years postdiagnosis. Compared HbA_1C levels at diagnosis among age subgroups (i.e., 9.7 ± 1.9%, 10.4 ± 2.2%, and 11.4 ± 3.1% for the <5 years, 5–10 years, and ≥10 years, resp.; ).

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