A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes

Figure 4

Plasma glucose (a, b) and insulin (c, d) levels during an IVGTT in low (a, c) and high (b, d) fat-fed mice treated with three consecutive once-daily doses of vehicle or 30, 50, or 75 mg/kg STZ. (e) First-phase insulin responses during the IVGTT, computed as the ratio of incremental areas under the curve for insulin/glucose from 0–5 minutes in mice treated with three consecutive once-daily doses of vehicle or 30, 50, or 75 mg/kg STZ. Treatment groups are denoted as follows: low fat—vehicle, open circles (); low fat—30 mg/kg STZ, open squares (); low fat—50 mg/kg STZ, open triangles (); high fat—vehicle, closed circles (); high fat—30 mg/kg STZ, closed squares (); high fat—50 mg/kg STZ, closed triangles (); and high fat—75 mg/kg STZ, × (). Data are . versus high fat—vehicle.

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