Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy

Table 3

(a) DN effector proteins differentially abundant in the cohort comparisons and (b) losartan treatment key proteins differentially abundant in the cohort comparisons.

(a)

Protein name	Basal versus control	Treated versus basal	Treated versus control
Osteopontin	Downregulated	Upregulated	Downregulated
Neprilysin	—	Downregulated	—
Fibronectin	Downregulated	—	Downregulated
Kininogen-1	—	—	Downregulated
VCAM-1	Downregulated	—	—

(b)

Protein name	Basal versus control	Treated versus basal	Treated versus control
Neprilysin	—	Downregulated	—
VCAM-1	Downregulated	—	—
Kininogen-1	—	—	Downregulated
Alpha-2-M	—	—	Upregulated

Cohort used as reference group. VCAM-1: vascular cell adhesion protein 1; Alpha-2-M: alpha-2-macroglobulin; —: no changes observed.