|
| Year | First author | Ref | Metabolomics technique | Sample type | Surgery type | Studied disease | Group size | Time points |
|
| 2017 | Liu, Ruixin | [42] | Untargeted and targeted (amino acids) | HPLC-MS and GC-MS | Human and animal (mice C57BL/6) | Serum | SG | Obesity | 29 (23 obese and 6 cases) | Before and one and three months after surgery |
| 2016 | Zhao, Linjing | [51] | Targeted (FFA) | UPLC-QTOF MS | Human | Serum | RYGB | Obesity and T2DM | 419 individuals (38 obese and diabetic after RYGB and 381 diabetic and nondiabetic with overweight or obesity) | Baseline, 1 year after RYGB |
| 2016 | Narath, Sophie H. | [32] | Untargeted | LC-HRMS, HILIC | Human | Serum | RYGB | Obesity | 44 patients | 2–4 weeks before surgery (PRE), 1–3 weeks after surgery (POST), and one year after surgery follow-up (FU) |
| 2016 | Lopes, Thiago I.B. | [33] | Untargeted | 1H NMR | Human | Plasma | RYGB | Obesity and T2DM | 10 subjects | Before and 12 months after surgery |
| 2016 | Sarosiek, Konrad | [44] | Untargeted | UHPLC-MS/MS and GC-MS | Human | Serum | SG or full GB | Obesity and T2DM | 15 patients (nondiabetic with SG and diabetic with SG or GB) | Baseline (prior to diet/surgery) and 14 and 28 days after surgery) |
| 2016 | Jung, Jeeyoun | [45] | Untargeted and targeted | 1H NMR | Animal (rats, 12-wk-old male Sprague-Dawley) | Serum and liver tissue | DJB | Surgery impact | 15 serum (7 sham, 8 DJB), 16 tissue (7 sham, 9 DJB) | No time points, controls versus DJB rats |
| 2016 | Chouiali, Ahlem | [48] | Targeted (vit. D) | LC-MS (QQQ) | Human | Serum | BPD | Bariatric population supplemented with vit. D | 48 healthy subjects, post-BPD: 44 supplemented with vit. D3 and 30 with vit. D2 | During patients follow-up |
| 2016 | Nemati, Reza | [30] | Targeted (NEFAs) | LC-MS/MS (QQQ) | Human | Plasma | LGB (Roux), LSG | Obesity and T2DM | 38 obese patients—11 GBP, 14 SG, 13 VLCD | Before and 3 days after intervention |
| 2016 | García-Alonso, Veronica | [50] | Targeted (eicosanoids) | LC-MS/MS (QQQ) | Human | Omental adipose tissue | “Laparoscopic bariatric surgery” | Regulatory actions of PGs in human omental WAT from obese patients | 12 obese individuals after bariatric surgery and 10 patients without obesity after laparoscopic cholecystectomy | Surgery versus controls |
| 2016 | Bankoglu, Ezgi Eyluel | [13] | Targeted (8-oxoGua, 8-oxodG, 8-oxoGuo) | LC-MS/MS (QQQ) | Animal (rats, 12-wk-oldmale Zucker) | Urine | RYGB | Obesity, oxidative/nitrative stress, genomic damage | 15 RYGB, 17 sham surgery | 0 and 27 days |
| 2016 | Stratmann, B. | [49] | Targeted (lipoproteins) | 1H NMR | Human | Serum | DJBL | Morbid obesity and T2DM | 18 subjects, finally 16; lipidome for 10 patients | NMR lipidomics baseline and 12 months |
| 2016 | Luo, Ping | [25] | Untargeted | UPLC-MS | Human | Serum | RYGB | Obesity and T2DM | 35 subjects—23 remission, 12 nonremission of T2DM | At baseline and 6 and 12 months after RYGB |
| 2015 | Gralka, Ewa | [38] | Untargeted | 1H NMR | Human | Serum | SG, proximal or distal RYGB | Obesity | 106 obese patients (19 SG, 27 proximal RYGB, 60 distal RYGB), 19 normal weight volunteers, 30 subject with matched BMI | Before and 3, 6, 9, and 12 months after procedures |
| 2015 | Bojsen-Moller, Kristine N. | [34] | Targeted (leucine, phenylalanine) | GC-MS | Human | Plasma | RYGB | Obesity | 10 obese subject after RYGB (1 out BCZ complications); 9 obese glucose-tolerant | Before and 3 months after surgery |
| 2015 | Calvo, Nahum | [40] | Untargeted | 1H NMR | Human | Hepatic tissue | LSG | Nonalcoholic fatty liver disease (NAFLD) | 47 patients, finally included 19 | Before (<24 h) and 12 months after surgery |
| 2015 | Modesitt, Susan C. | [7] | Untargeted | GC-MS and UPLC-MS/MS | Human (women only) | Serum | LRYGB, LSG, LGB, open RYGB | Endometrial histology, obesity | 71 (41 LRYGB, 17 LSG, 8 LGB, 2 open RYGB, 3 no surgery) | Pre- and postoperatively |
| 2015 | Arora, Tulika | [36] | Untargeted | GC-MS and UPLC-MS | Human | Plasma | RYGB | Insulin-resistant morbidly obese subjects, some with diabetes | 16 patients | Presurgery and 4 and 42 days after surgery |
| 2015 | Lopes, Thiago I.B. | [35] | Untargeted and targeted (FA) | 1H NMR and GC-MS | Human | Plasma | RYGB | Obesity and T2DM | 10 patients | Before and 12 months after surgery |
| 2015 | Hertel, Johannes | [26] | Untargeted | 1H NMR | Human | Urine | SG, RYGB | Measurement of biological age based on metabolomics profiles, expanded on clinical samples of obese patients after bariatric surgery | 4068 individuals from SHIP-0 at baseline, 996 from SHIP-TREND;38 individuals after surgery | For operated patients: preoperative and postoperative (median follow-up 366.5 days) |
| 2014 | Kwon, Hyuk Nam | [37] | Untargeted and targeted (3-HB) | 1H NMR and GC-MS | Human | Plasma | RYGB, DJB | Patients who underwent surgery for uncontrolled diabetes | 22 patients | Metabolic profile 7 days after surgery |
| 2014 | Oberbach, Andreas | [31] | Targeted (sUA) | LC-MS/MS | Human | Serum | LSG and RYGB | Obesity | 10 severely obese adolescents (5 LSG, 5 RYGB) and 17 normal weight | Pre- and 12 months postoperatively |
| 2014 | Kaska, Lukasz | [52] | Targeted (FA) | GC-MS | Human | Serum | Analysis before the surgery | Morbid obesity, nondiabetic | 16 women | Samples from the day of surgery |
| 2014 | Jüllig, Mia | [27] | Untargeted | GC-MS | Human | Plasma | GB, SG | Subject with T2D undergoing GBP or SG | 15 subjects (8 GBP, 7 SG) | 3 days before and 3 days after surgery |
| 2014 | Heffron, Sean P. | [46] | Targeted | NMR spectroscopy | Human | Fasting blood samples | LGB | Obesity and obesity-relatedcomorbidity | 50 obese patients, 47 with completed follow-up | Baseline and 1, 2, 3, 4, and 5 years after operation |
| 2013 | Sledzinski, Tomasz | [28] | Targeted (FA) | GC-MS | Human and animal (Rats, 10-wk-old male Wistar) | Serum and adipose tissue | RYGB | Obesity | 16 obese nondiabetic women after RYGB, 20 rats (10 controls, 10 diet) | Tissue from women during surgery, rats one month after starting diet |
| 2013 | Ashrafian, Hutan | [11] | Untargeted | 1H NMR and UPLC-MS | Animal (rats, male Wistar) | Plasma and heart tissue extracts | RYGB | Bariatric surgical on cardiac metabolites | 27 rats—13 RYGB, 14 sham-operated | 8 weeks postoperation |
| 2012 | Oberbach, Andreas | [41] | Targeted | LC-MS | Human | Serum | LSG | Morbid obesity (children) | 6 obese children | Pre- and 6 months postoperatively |
| 2012 | Friedrich, Nele | [39] | Untargeted and targeted | 1H NMR | Human | Urine | SG, RYGB | Obesity | 50 patients (39 SG, 11 RYGB) 50 controls; finally 47 preoperation, 45 postoperation, 48 controls | Pre- and postoperatively (3, 4, 5, 6, 7, and 9 days postsurgery) |
| 2011 | Oberbach, Andreas | [43] | Targeted | LC-MS | Human | Serum | SG | Obesity | 14 obese after SG, 12 on hypocaloric diet, 17 healthy subjects | Comparison obese subjects and controls, samples six month after treatment |
| 2010 | Calvani, R. | [47] | Untargeted | 1H NMR | Human | Urine | BPD, RYGB | Morbid obesity (insulin resistant) | 15 obese subjects, 10 matched controls in general, 2 subjects after bariatric surgery | 30 and 90 days after surgery |
|
