Application of Metabolomics to Study Effects of Bariatric Surgery

Table 2

The detailed results from the pathway analysis.

Pathway name		FDR	Impact
Aminoacyl-tRNA biosynthesis			0.16902
Glycine, serine, and threonine metabolism			0.48394
Nitrogen metabolism
Phenylalanine metabolism		0.01177	0.20468
Cysteine and methionine metabolism		0.015299	0.54182
Citrate cycle (TCA cycle)	0.0014874	0.015453	0.28353
Taurine and hypotaurine metabolism	0.0014874	0.015453	0.46583
Valine, leucine, and isoleucine biosyntheses	0.0015467	0.015453	0.12084
Propanoate metabolism	0.0017384	0.015453	0.07344
Nicotinate and nicotinamide metabolism	0.0020764	0.016611	0.06485
Alanine, aspartate, and glutamate metabolism	0.0041218	0.029977	0.53182
Arginine and proline metabolism	0.0045157	0.030104	0.4641
Synthesis and degradation of ketone bodies	0.0051467	0.031672	0.7
Pyrimidine metabolism	0.0057644	0.032939	0.22308
Methane metabolism	0.0062792	0.033489	0.18217
Glutathione metabolism	0.011733	0.058666	0.34321
Glyoxylate and dicarboxylate metabolism	0.016707	0.077524	0.1897
Pyruvate metabolism	0.017733	0.077524	0.42654
Purine metabolism	0.018412	0.077524	0.30417
Pantothenate and CoA biosyntheses	0.031274	0.1251	0.0
D-Glutamine and D-glutamate metabolism	0.033063	0.12596	0.35294
Valine, leucine, and isoleucine degradation	0.048233	0.16777	0.0835
Butanoate metabolism	0.048233	0.16777	0.18589
Glycolysis or gluconeogenesis	0.053056	0.17685	0.09576
Linoleic acid metabolism	0.074881	0.23962	0.65625
Cyanoamino acid metabolism	0.087776	0.27008	0.0
Primary bile acid biosynthesis	0.091995	0.27258	0.08068
D-Arginine and D-ornithine metabolism	0.096427	0.27551	0.0
Sulfur metabolism	0.11609	0.31315	0.06614
Glycerophospholipid metabolism	0.11743	0.31315	0.17061
Galactose metabolism	0.13757	0.35503	0.24385
Vitamin B6 metabolism	0.16454	0.39889	0.24174
Glycerolipid metabolism	0.16454	0.39889	0.27975
Thiamine metabolism	0.21633	0.50901	0.0
Fatty acid biosynthesis	0.23092	0.52123	0.0
Sphingolipid metabolism	0.23455	0.52123	0.04244
Tyrosine metabolism	0.24772	0.5356	0.12506
Phenylalanine, tyrosine, and tryptophan biosyntheses	0.27174	0.57208	0.008
beta-Alanine metabolism	0.29058	0.59605	0.0
alpha-Linolenic acid metabolism	0.30951	0.61902	0.20335
Histidine metabolism	0.34348	0.67021	0.21313
Selenoamino acid metabolism	0.44198	0.84186	0.00321
Biotin metabolism	0.5361	0.9974	0.0
Ascorbate and aldarate metabolism	0.59325	1.0	0.13047
Arachidonic acid metabolism	0.60998	1.0	0.2595
Lysine degradation	0.62333	1.0	0.14675
Glycosylphosphatidylinositol- (GPI-) anchor biosynthesis	0.62401	1.0	0.0
Tryptophan metabolism	0.62432	1.0	0.24863
Pentose phosphate pathway	0.64591	1.0	0.0
Lysine biosynthesis	0.64591	1.0	0.09993
Starch and sucrose metabolism	0.66555	1.0	0.0765
Pentose and glucuronate interconversions	0.70426	1.0	0.02401
Porphyrin and chlorophyll metabolism	0.71374	1.0	0.05249
Inositol phosphate metabolism	0.75054	1.0	0.18387
Riboflavin metabolism	0.76996	1.0	0.0
Caffeine metabolism	0.76996	1.0	0.0305
Fatty acid elongation in mitochondria	0.84921	1.0	0.0
Terpenoid backbone biosynthesis	0.90126	1.0	0.0
Ubiquinone and other terpenoid-quinone biosyntheses	0.92013	1.0	0.0
Amino sugar and nucleotide sugar metabolism	0.9439	1.0	0.0
Fructose and mannose metabolism	0.96591	1.0	0.0
Steroid hormone biosynthesis	0.96878	1.0	0.10049
Fatty acid metabolism	0.97043	1.0	0.02959

Raw is the original value calculated from the enrichment analysis; the FDR is the value adjusted using false discovery rate; the Impact is the pathway impact value calculated from pathway topology analysis.