Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Figure 1

Effects of intraperitoneal injection of PCPA (500 mg/kg) for 3 days on body weight changes (a) and expression of hypothalamic Tph2 and 5-HT2A receptors (b) in mice. Basal body weight was 22.1 ± 0.2 g in controls and 21.8 ± 0.2 g in the PCPA-treated mice. Data are presented as the mean values ± SEM (/group of animals). .

(a)

(b)