Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Figure 4

Effects of intraperitoneal injection of liraglutide (100 μg/kg) or saline on food intake in C57BL6J mice intraperitoneally injected with TCB-2 (2.5 mg/kg). Liraglutide was injected 14 h later (a) or 24 h later (b). Intake of chow pellets was measured for the next hour and then at 2 h. Body weight of C57BL6J mice without TCB-2 was 23.9 ± 0.2 g in the saline controls and 24.2 ± 0.3 g in the liraglutide-treated group. Body weight of C57BL6J mice treated with TCB-2 was 23.9 ± 0.2 g in the saline controls and 24.2 ± 0.3 g in the TCB-2 and liraglutide-treated group. C, saline controls; 2AR, TCB-2L treated mice; L, liraglutide-treated mice, and 2AR + L, TCB-2 and liraglutide-treated mice. Data are presented as the mean values ± SEM (/group of animals). .

(a)

(b)