Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes

Table 9

Genotype distributions of GIP SNPs in male < 55 y and female < 65 y in dominant inheritance mode.

Gene	SNPs genotype	CAD positive n (%)	CAD negative n (%)	OR (95% CI)		OR (95% CI)
GIP	rs2291725
	C/C	55 (51.4)	44 (34.9)	1.971 (1.164–3.339)	0.011	1.346 (0.958–1.892)	0.087
	C/T + T/T	52 (48.6)	82 (65.1)
	rs8078510
	G/G	85 (79.4)	77 (62.1)	2.358 (1.304–4.266)	0.004	1.589 (1.071–2.357)	0.021
	G/A + A/A	22 (20.6)	47 (37.9)

OR, 95% CI, and p were calculated by logistic regression analysis after adjustment for other known CAD risk factors (age, BMI, smoking status, dyslipidemia history, hypertension history, and diabetic duration).