Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study

Table 3

Sensitivity analysis in the association between changes of hyperuricemia and incident diabetes.

Changes of hyperuricemia	Total	Diabetes (, %)	RR (95% CI)
			Model 1	Model 2^†	Model 3^‡
No hyperuricemia	11782	465 (3.95)	1.00	1.00	1.00
Remittent hyperuricemia	1182	100 (8.46)	1.70 (1.36-2.11)	1.42 (1.13-1.78)	1.25 (1.00-1.55)
Incident hyperuricemia	830	75 (9.04)	1.98 (1.54-2.53)	1.70 (1.33-2.18)	1.51 (1.18-1.93)
Persistent hyperuricemia	1609	201 (12.49)	2.42 (2.03-2.89)	1.93 (1.61-2.32)	1.65 (1.38-1.96)

Data were relative risks (RRs) and 95% confidence intervals (CIs). Hyperuricemia was defined as serum uric acid level greater than 6.8 mg/dL. Adjusted for age and sex at baseline. ^†Adjusted for variables in model 1 as well as education level, smoking, alcohol consumption, physical activity, family history of diabetes, and body mass index at baseline. ^‡Adjusted for variables in model 2 as well as systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and high-density lipoprotein cholesterol at baseline.