Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study

Table 4

The association between percentage change of serum uric acid and incident diabetes.

Percentage change of serum uric acid	Total	Diabetes (, %)	RR (95% CI)
			Model 1	Model 2^†	Model 3^‡
≤ −10%	4133	223 (5.40)	0.81 (0.69-0.95)	0.83 (0.71-0.99)	0.84 (0.72-0.99)
> −10% and ≤10%	7663	412 (5.38)	1.00	1.00	1.00
>10% and ≤30%	2900	163 (5.62)	1.40 (1.17-1.68)	1.34 (1.12-1.60)	1.30 (1.08-1.55)
>30%	707	43 (6.08)	2.00 (1.48-2.72)	1.85 (1.37-2.50)	1.71 (1.27-2.30)
for trend			<0.0001	<0.0001	<0.0001

Data were relative risks (RRs) and 95% confidence intervals (CIs). Adjusted for age, sex, and serum uric acid at baseline. ^†Adjusted for variables in model 1 as well as education level, smoking, alcohol consumption, physical activity, family history of diabetes, and body mass index at baseline. ^‡Adjusted for variables in model 2 as well as systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and high-density lipoprotein cholesterol at baseline.