Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy

Figure 2

The expression of STRs and associated signaling components was downregulated in renal tissue of DM mouse models. Representative images of immunohistochemistry (a) and immunofluorescence (b) staining showed that T1R2 and T1R3 expression was downregulated in renal tissue of DM mouse models. T1R2 and T1R3 expression was represented as the positive yellow-brown stained area (immunohistochemistry, 200×) or green fluorescence area (immunofluorescence, 200×). (c) STR-associated signaling component (α-gustducin, PLCβ2, and TRPM5) mRNA expression in renal tissues was detected by qRT-PCR. Data are presented as means ± SD; the gray graph confirmed these trends. versus NC group.

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