Serum Levels of Interleukin-13 Increase in Subjects with Insulin Resistance but Do Not Correlate with Markers of Low-Grade Systemic Inflammation
Table 1
Demographic, anthropometric, metabolic, and immunological characteristics of the study subjects.
Parameters
NIR
IR
Gender (W/M)
23/24
22/23
n.s.
Age (years)
31.02 ± 10.41
36.75 ± 11.18
n.s.
BMI (kg/m2)
26.82 ± 4.89
32.92 ± 2.34
<0.001
Waist circumference (cm)
86.87 ± 13.00
105.00 ± 6.21
<0.001
Body fat (%)
26.61 ± 8.15
36.99 ± 7.42
<0.001
Waist-to-hip ratio
0.92 ± 0.12
0.97 ± 0.04
n.s.
SBP (mmHg)
128.4 ± 3.57
127.9 ± 4.28
n.s.
Blood glucose (mg/dl)
84.17 ± 9.79
104.9 ± 5.58
<0.0001
Serum insulin (mU/l)
11.16 ± 2.38
21.56 ± 1.89
<0.0001
HOMA-IR
2.28 ± 0.39
5.59 ± 0.64
<0.0001
Total cholesterol (mg/dl)
193.7 ± 10.28
198.0 ± 10.18
n.s.
Triglycerides (mg/dl)
159.40 ± 37.93
256.6 ± 13.19
<0.0001
TNF-α (pg/ml)
8.26 ± 3.45
30.29 ± 3.93
<0.0001
IL-10 (pg/ml)
100.8 ± 26.41
37.04 ± 10.36
<0.0001
Mon-CD11c+CD206− (%)
28.30 ± 17.18
60.93 ± 20.68
<0.001
Mon-CD11c−CD206+ (%)
24.23 ± 9.46
6.05 ± 5.71
<0.0001
Data are expressed as mean ± standard deviation. Significant differences were estimated by means of performing two-way Student’s t-test. Differences were considered significant when . W: women; M: men; BMI: body mass index; SBP: systolic blood pressure; HOMA-IR: homeostatic model assessment of insulin resistance; TNF-α: tumor necrosis factor alpha; IL: interleukin; Mon CD11c+CD206−: proinflammatory monocytes; Mon CD11c−CD206+: anti-inflammatory monocytes; n.s.: nonsignificant differences.
