The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers
Table 1
Comparison of food, water intake, and body weight (b.wt) change of nondiabetic controls, diabetic controls, and diabetic rats treated with MB, metformin, and insulin during a 5-week study ( in each group). Values are expressed as .
Parameter
Treatment
Time (weeks)
1
2
3
4
5
Food intake (g/100 g)
NC
11.9 ± 3.4
12.2 ± 1.6
12.3 ± 1.7
13.0 ± 0.4
12.9 ± 0.9
DC
27.6 ± 1.2
25.4 ± 1.4
16.7 ± 0.4
28.0 ± 1.1
24.8 ± 0.3
MB
10.0 ± 2.1
10.2 ± 2.6
16.4 ± 1.1
26.47 ± 2.4
18.9 ± 0.6
INS
19.2 ± 2.2
18.8 ± 1.9
11.2 ± 0.8
15.5 ± 3.0
14.2 ± 0.9
MTF
28.2 ± 0.6
22.7 ± 0.5
21.8 ± 0.5
19.8 ± 0.7
26.8 ± 1.7
Water intake (mL/100 g)
NC
30 ± 8.2
35 ± 1.4
32.5 ± 8.5
45 ± 9.6
51.2 ± 7.2
DC
60 ± 9.6
61.3 ± 12.9
95.0 ± 3.7
91.3 ± 3.4
96 ± 1.0
MB
72.5 ± 2.5
67.0 ± 4.1
73.8 ± 8.3
78.7 ± 9.6
76 ± 1.0
INS
73.0 ± 4.4
76.3 ± 9.4
76.3 ± 0.1
76.4 ± 4.8
74.2 ± 2.3
MTF
68.8 ± 3.1
41.3 ± 7.5
45.6 ± 2.5
45.2 ± 2.3
43.8 ± 1.1
% b.wt change/week
NC
44.7 ± 9.4
69.7 ± 5.9
76 ± 8.6
90.7 ± 11.1
92.5 ± 9.9
DC
−72 ± 8.6
−87.2 ± 20
−77.5 ± 9.8
−77.5 ± 12
−80 ± 7.4
MB
−13.8 ± 8
−11.1 ± 5
−19.5 ± 6.2
−15.3 ± 6.1
−40.5 ± 11
INS
18.5 ± 13.9
3.2 ± 15.7
30.0 ± 16.2
38.3 ± 18.1
28.3 ± 3.2
MTF
−23 ± 7.3
−6 ± 6.8
−32 ± 2.9
−11 ± 17.3
−37 ± 3.2
Glucose (mmol/L)
NC
5.1 ± 0.3
5.1 ± 0.4
4.9 ± 0.3
5.8 ± 0.5
5.3 ± 0.1
DC
33.1 ± 1.5#
33.1 ± 0#
33.4 ± 0.2#
33.0 ± 0.8#
33.2 ± 0.2#
MB
27.2 ± 0.3
29.1 ± 0.3
24.2 ± 1.9
25.6 ± 0.6
26.4 ± 1.0
INS
30.7 ± 0.8
23.2 ± 2.6
21.1 ± 2.3
21.9 ± 1.6
17.1 ± 0.9
MTF
28.0 ± 2.1
26.0 ± 1.4
25.7 ± 0.5
24.6 ± 0.9
24.8 ± 0.6
by comparison with nondiabetic control and by comparison with diabetic control.
