Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model

Figure 4

Plasma levels of metabolic hormones after a STZ injection. Plasma was collected at week 21and week 25 after a STZ injection under nonfasting condition for the quantification of hormone levels. STZ challenge significantly reduced insulin (a) and amylin (b) levels compared to sham rats. The insulin level improved slightly between weeks 21 and 25 () in STZ-injected rats. STZ injection did not show significant effect on glucagon (c) and PP levels (d). GIP decreased in diabetic animals although statistical significance was only reached at week 25 and not at week 21 may be due to small sample numbers (e). GLP-1 increased in diabetic animals at week 25 but not week 21 (f). –5 at week 21, and –10 at week 25, mean ± s.e. Student’s t-test, , , , (diabetic rats compared to normal sham rats).

(a) Insulin

(b) Amylin

(c) Glucagon

(d) PP

(e) GIP

(f) GLP-1