Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model

Table 1

Animal groups used to assess age-dependent STZ toxicities.

Groups	Group 1; (BW 220–400 g)	Group 2; (BW 401–500 g)	Group 3; (BW 501–600 g)	Total
Age (weeks)	6–11	12–17	18–23
Number of rats receiving single STZ 65 mg/kg i.v.	50	29	20	99
Number of rats receiving single STZ 50 mg/kg i.v.	0	0	14	14
Number of rats receiving two STZ 50 mg/kg i.v. 3 days apart	17	0	0	17
Total rats injected with STZ	67	29	34	130
Total sham-injected rats	16	4	3	23