Skeletal Status, Body Composition, and Glycaemic Control in Adolescents with Type 1 Diabetes Mellitus

Table 3

Relationship between disease duration, insulin requirement, glycaemic control, and skeletal and body composition Z-score values (for age- and sex- dependent reference data for healthy subjects) in T1DM patients.

Variable (Z-scores)^/1	Diabetes duration		Insulin requirement		HbA1c
						p
Z TBBMD	−0.260	0.049	−0.423	0.001	−0.283	0.031
Z TBBMC	−0.253	0.056	−0.302	0.021	−0.331	0.011
Z S24BMD	−0.163	0.221	−0.324	0.013	−0.133	0,321
Z S24BMC	−0.121	0.356	−0.242	0.067	−0.246	0.063
Z TBBMC/LBM	−0.158	0.238	−0.386	0.003	−0.182	0.171
Z S24BMC/LBM	−0.094	0.481	−0.272	0.039	−0.129	0.334
Z LBM	−0.246	0.062	−0.110	0.410	−0.345	0.008
Z FM	0.046	0.731	−0.111	0.408	0.013	0.921
Z FM/LBM	0.123	0.359	−0.115	0.390	0.054	0.689
Diabetes duration (y)	—	—	0.303	0.021	0.265	0.045
Insulin requirement (U/kg/d)	0.303	0.021	—	—	0.626	0.001
HbA1c (%)	0.265	0.045	0.626	0.001	—	—

Results are expressed as correlation coefficient () and two-tailed statistical significance (); -values adjusted for age, sex, pubertal stage, height, weight, and physical activity level; -value ≤ 0.05; ^/1Z-scores for DXA parameters calculated according to age- and sex-dependent reference data for healthy subjects; TBBMD — total body bone mineral density; TBBMC — total body bone mineral content; LBM — lean body mass; FM — fat mass; S24BMD — bone mineral density, lumbar spine L2–L4; S24BMC — bone mineral content, lumbar spine L2–L4; S24BMC/LBM — bone mineral content, lumbar spine L2–L4/lean body mass ratio; TBBMC/LBM — total body bone mineral content/lean body mass ratio; FM/LBM — fat mass/lean body mass ratio.