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Journal of Diabetes Research
Volume 2018, Article ID 8939235, 12 pages
https://doi.org/10.1155/2018/8939235
Research Article

Vitamin D, Gestational Diabetes, and Measures of Glucose Metabolism in a Population-Based Multiethnic Cohort

1Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway
2Department of Child and Adolescence Medicine, Akershus University Hospital, Lørenskog, Norway
3Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
4Department of Noncommunicable Diseases, Norwegian Institute of Public Health, Oslo, Norway
5Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway
6Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
7General Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway

Correspondence should be addressed to Åse Ruth Eggemoen; on.oiu.nisidem@neomegge.r.a

Received 14 October 2017; Revised 28 December 2017; Accepted 7 February 2018; Published 19 April 2018

Academic Editor: Eusebio Chiefari

Copyright © 2018 Åse Ruth Eggemoen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. We explored associations between maternal 25-hydroxyvitamin D (25(OH)D) status during pregnancy and gestational diabetes (GDM) and other measures of glucose metabolism. Methods. We analysed 25(OH)D at 15 and 28 gestational weeks (GW) in 745 multiethnic pregnant women attending antenatal care units in Oslo, Norway, between 2008 and 2010. GDM was diagnosed with a 75 g oral glucose tolerance test at 28 GW. Separate regression analyses were performed to investigate associations between 25(OH)D and GDM and measures of glucose metabolism. Results. A higher proportion of ethnic minority women had GDM () and low 25(OH)D () compared to Europeans. In logistic regression analyses, 25(OH)D < 50 nmol/L was associated with GDM after adjusting for age, parity, education, and season (OR 1.6; 95% CI 1.1–2.2). After additional adjustments for variables reflecting fat mass (skinfolds or BMI) and ethnicity, the association disappeared with ethnicity having a much stronger effect than the adiposity variables. We got similar results exploring effects on other measures of glucose metabolism and when change in 25(OH)D from inclusion to 28 GW was taken into account. Conclusions. Vitamin D deficiency was not associated with GDM or glucose metabolism in a multiethnic population-based study, after adjustments for confounding factors, in particular ethnicity.