Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage

Figure 11

Representative photomicrographs of VEGF (red) and GFAP (green) double staining of the retina in the NC11w, DM11w, DM11w + LR, and DM11w + B groups. VEGF immunoreactivity was localized in GFAP-labeled astrocytes (single arrow) and blood vessels (asterisk). (b, C-2) GFAP expression appeared to be enhanced in the DM11w and DM11w + LR, consistent with the expression of VEGF in these two groups. (A-1, 2, D-1, 2) By contrast, both VEGF and GFAP expressions were relatively lower in the NC11w and DM11w + B groups. Note the dilated blood vessels in diabetic retina at the DM11w + LR group (asterisk). Bar = 50 μm.

(a)

(b)

(c)

(d)