Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage

Figure 2

Representative photomicrographs of nNOS (red) and NeuN (green) double staining of the retina in the NC and DM6w groups. nNOS immunoreactivity was localized in NeuN-labeled neurons (single arrow) and blood vessels (asterisk), and it was relatively higher in the DM6w group (B-1) than in the NC group (A-1). Moreover, coexpression of nNOS and NeuN was apparent in the DM6w group (B-3) compared to the NC group (A-3). Blood vessels appeared to be dilated in diabetic retina at the DM6w group (asterisk). Note the enhanced nNOS staining and smaller size of NeuN-positive neurons at the DM6w group compared with the control group. Bar = 50 μm.

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