Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Figure 1

Cardiac ultramicrostructure was preserved in SPR-treated rats. (a–c) Representative electron micrographs for mitochondria, myofibrils, and sarcoplasmic reticulum, respectively. In the NDC group, normal ultrastructure was observed in the heart tissue. Loss of cristae, irregular arrangement of myofibrils, and enlarged sarcoplasmic reticula were observed in the STZ + NS group. Pathological changes in the STZ + SPR group were significantly reduced compared to those of the diabetic group. Red, blue, and green arrows indicate mitochondria, myofibrils, and sarcoplasmic reticulum, respectively.

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