Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Figure 4

SPR protected against myocardial hypertrophy and fibrosis in DCM. (a) Representative immunohistochemical micrographs of cardiac tissue stained with collagen 1 and TGF-β1 (original magnification 20×). (b) The IHC scores of heart sections for collagen 1 and TGF-β1 IHC staining. (c) The protein expression of collagen 1 and TGF-β1 examined by Western blot. (d) The quantification data of Western blot for collagen 1 and TGF-β1. (e) Gene expression of collagen 1 and TGF-β1 for these 3 groups. , data are shown as . , , and vs. NDC group; , , and vs. STZ + NS group.

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