Journal of Diabetes Research / 2018 / Article / Fig 7

Research Article

Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Figure 7

SPR aborted the aggregated oxidative stress induced by aldosterone in a myocardioblast cell line. (a–c) Gene expression of GCLC, NRF-1, and Nox4 in H9C2 cells treated with aldosterone (10−7 mmol/L), with or without SPR (10−7 mol/L), for 72 h. (d) Cellular ROS levels after treatment with aldosterone, with or without SPR. , data are shown as . , , and vs. control group; and vs. aldosterone-treated group.

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