Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study
Protein expression of major proteins in skeletal muscle from patients in treatment with simvastatin (yellow squares) and matched controls (grey circles). (a) Lipid uptake-related proteins EL (endothelial lipase), LPL (lipoprotein lipase), FAPBpm (plasma membrane-bound fatty acid-binding protein), and CD36. (b) Lipid synthesis-related protein DGAT 1 and 2 (diacylglycerol acyltransferase). (c) Lipid droplet regulation, perilipins 2, 3, and 5. (d) Lipolysis: ATGL (adipose triacylglycerol lipase) and HSL (hormone-sensitive lipase). Data are mean ± SE, . Data are presented as relative to mean of the control. Representative blots are shown in Figure 2.