Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes

Figure 5

Heat map representing the immunological changes induced by GAD-alum treatment. Variations were calculated as the ratio of the values at 90 and 180 days with respect to the baseline. Patients received GAD-alum injections into the lymph nodes (LNs, ) or subcutaneously (SC, ), and they were stratified from left to right according to their clinical outcome at 180 days. Clinical variables are expressed as percentage of change from baseline (%). At 90 days, max. stimulated, and AUC C-peptide were not calculated, as meal tolerance tests were not performed, and are represented by “×”. The color scales illustrate the posttreatment increase (green) or decrease (red) of variables in relation to baseline values.