Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer

Table 2

Results of Ang2 and MV marker measurements, before and after of therapy.

							value^1 (NPWT vs. ST, before therapy)	value^1 (NPWT vs. ST, after therapy)
	NPWT ()			ST ()
	Before therapy	After therapy	value	Before therapy	After therapy	value
Ang2 (ng/mL)	3.54 (2.40-5.40)	3.32 (2.33-4.61)	0.01^2	3.00 (2.36-4.14)	2.91 (2.17-4.32)	0.98^3	0.21	0.38
	NPWT ()			NPWT ()
	Before therapy	After therapy	value	Before therapy	After therapy	value
MV Tie+	3.47 (1.80-5.97)	4.54 (3.14-7.06)	0.41^3	4.49 (2.79-14.70)	4.57 (1.75-12.23)	0.28^2	0.32	0.98
MV AnnV+	1.97 (1.51-3.15)	3.91 (1.68-6.33)	0.07^2	2.10 (1.04-3.56)	2.16 (1.13-3.79)	0.52^3	0.51	0.16
MV Iso+	0.74 (0.42-1.36)	1.17 (0.53-1.84)	0.57^2	0.65 (0.57-1.22)	0.74 (0.69-2.26)	0.33^2	0.73	0.95
Total MVs (10^6 events/μL)	5.12 (3.06-8.89)	3.45 (0.94-9.09)	0.55^2	15.26 (4.42-24.24)	13.14 (9.30-15.83)	0.26^3	0.07	0.03

Data shown as and median (IQR). The units of Tie2+, AnnV+, and Iso+ are positive counts per 1000 events. values calculated for ¹Mann-Whitney test, ²Wilcoxon rank test, or ³-test.