Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling

<div>Immunohistochemical analysis reflecting the activation of the HIF signalling pathway following VH298 treatment. (a1–c1) VH298 treatment significantly enlarged HIF-1<i>α</i>-, hydroxy-HIF-1<i>α</i>-, and VEGF-A-positive areas (brown) compared to PBS treatment. (a2–c2) Values expressed as the positive percentage of each group. 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Journal of Diabetes Research

fig6

Figure 6

Figure 6: Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling 

Figure 6 | Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling 