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Journal of Diabetes Research
Volume 2019, Article ID 2435261, 6 pages
Research Article

Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus

1Department of Physiology, Faculty of Medicine, University of Khartoum, 11111, Sudan
2Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, 11111, Sudan

Correspondence should be addressed to Afraa Musa; moc.liamg@asumarfa

Received 19 February 2019; Revised 21 May 2019; Accepted 17 June 2019; Published 2 July 2019

Academic Editor: Mark Yorek

Copyright © 2019 Nimat Abuelwafaa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic peripheral neuropathy (DPN) involves sensory and motor nerves, resulting in demyelination as well as axonal degeneration. This study was conducted to describe the pattern of lower limb nerve involvement in children with type 1 diabetes mellitus (DM) based on the parameters of nerve conduction study (NCS). This cross-sectional study recruited 50 children with type 1 DM having mean disease duration of years who attended the referred clinic in Sudan Childhood Diabetes Center. Their mean age was years, 42% were males, and 58% were females. Twenty six matched healthy control subjects were involved; their mean age was years, 38.46% were males, and 61.54% were females. Bilateral NCS of the sensory and motor lower limb nerves was performed using Medelec Synergy machine. Interpretation of the patients’ results was based on our own control reference values. Data was analysed using IBM SPSS statistics. Out of the 50 diabetic patients, 44 (88%) had electrophysiological evidence of peripheral neuropathy (abnormalities in at least two of the electrophysiological parameters). The majority (68.2%) had motor involvement and 31.8% had sensorimotor, while none of them (0%) had pure sensory involvement. Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. The most frequently affected nerve was the common peroneal, followed by posterior tibial, and the least was the sural nerve. The most sensitive parameter was the common peroneal conduction velocity. Motor precedes sensory nerve involvement. The most frequent neurophysiological abnormality was the conduction slowing, and the common peroneal was the most vulnerable nerve. These findings signify generation of a protocol for early screening of neuropathy in children with type 1 diabetes.