The Association between Genomic DNA Methylation and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus

Table 3

TCSS as dependent variable in multiple stepwise regression analysis.

	Unstandardized coefficients		Standardized coefficients		value	95% confidence interval for
		Std. error	Beta			Lower bound	Upper bound
Constant	9.117	1.144	—	7.967	0.000	6.851	11.383
Duration	0.242	0.041	0.441	5.975	0.000	0.162	0.322
Genomic DNA methylation	-16.434	3.949	-0.300	-4.162	0.000	-24.253	-8.615
eGFR	-0.027	0.008	-0.253	-3.413	0.001	-0.043	-0.011

In multiple stepwise regression analysis, TCSS, as dependent variable, and the other 8 variables, age, duration, BMI, CRP, UACR, UA, eGFR, and genomic DNA methylation, as independent variables, were included in the same model. Only three variables, duration, genomic DNA methylation, and eGFR, were the risk factors of TCSS ().