Journal of Diabetes Research / 2019 / Article / Fig 2

Research Article

Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

Figure 2

HG induced the phosphorylation of the receptor tyrosine kinase of human HK2 cells. HK2 cells were treated with HG for 24 h and then subjected to western blotting assay. Representative blots of the total protein levels of PI3K, the phosphorylated Akt, and GSK-3β (a). The inhibitory phosphorylation of GSK-3β increased Snail-1 and β-catenin protein levels. The protein level of Nrf2 was decreased (b).

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