Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3<i>β</i> Signaling

<div>ROS regulation in human HK2 cells by SFN under high-glucose stress (assay by FACScan). High glucose induces an increase of intracytoplasmic ROS in human HK2 cells, but SFN treatment shows a left-shift pattern of the ROS curve.</div>

Journal of Diabetes Research

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Figure 4: Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3<i>β</i> Signaling 

Figure 4 | Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling 