Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4/ROS/p38 Pathway in Diabetic Nephropathy

Figure 8

Schematic representation of the mechanisms of the NOX-4/ROS/p38 pathway in podocyte injury in high glucose condition. HG significantly increases NOX-4 expression in podocyte. And NOX-4-induced ROS overproduction triggers cascade phosphorylation reaction of the p38 pathway. Accordingly, activation of the p38 pathway can decrease nephrin expression and induce podocyte apoptosis. Baoshenfang formula might protect podocyte from HG-induced injury via inhibiting the NOX-4/ROS/p38 pathway.