Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations

Table 4

Correlations between the determinants of tetrahydrobiopterin pathway and variables related to the diabetes in patients with diabetes foot ulcer.

Determinants	Group II			Group III
	Nitric oxide (μmol/L)	Neopterin (nmol/L)	Biopterin (nmol/L)	Nitric oxide (μmol/L)	Neopterin (nmol/L)	Biopterin (nmol/L)
Age (year)	-0.235	0.004	0.103	-0.382	0.121	0.1033
	0.067	0.974	0.409	0.004	0.369	0.409
Duration (year)	-0.099	0.104	0.215	-0.264	-0.041	0.227
	0.428	0.406	0.084	0.050	0.760	0.090
Fasting serum glucose (mg/dl)	-0.126	-0.162	0.085	0.062	0.008	0.064
	0.312	0.193	0.499	0.651	0.952	0.636
HbA1c%	-0.171	0.126	0.193	-0.243	-0.030	0.240
	0.176	0.322	0.126	0.089	0.834	0.089
Mean arterial blood pressure (mmHg)	-0.246	-0.014	0.103	-0.532	-0.089	0.212
	0.046	0.914	0.408	<0.001	0.516	0.116
Body mass index (kg/m^2)	0.100	0.122	0.095	-0.321	0.130	0.021
	0.427	0.331	0.449	0.016	0.336	0.877
Red cell distribution width CV (%)	0.026	0.142	0.001	-0.322	0.310	0.306
	0.837	0.254	0.995	0.012	0.019	0.021
Mean platelet volume (fL)	-0.009	-0.085	-0.169	-0.179	0.091	-0.060
	0.940	0.498	0.175	0.187	0.501	0.658
Platelet distribution width (%)	0.048	0.333	0.198	-0.284	0.204	0.047
	0.700	0.006	0.111	0.034	0.128	0.728
Erythrocyte sedimentation rate (mm/h)	-0.134	0.897	0.539	-0.191	0.933	0.505
	0.282	<0.001	<0.001	0.160	<0.001	<0.001
Serum nitric oxide (μmol/L)		-0.055	-0.154		-0.129	-0.321
		0.660	0.218		0.343	0.016
Serum neopterin (nmol/L)			0.518			0.540
			<0.001			<0.001

The results are expressed as Spearman correlation factor (above) and value (below) in each cell of the table.