Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population

Table 1

SNPs in CDKAL1 gene and risk of gestational diabetes mellitus^#.

SNPs	Genotypes	Cases	Controls	Additive		Dominant		Recessive		Codominant
				OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
rs4712527	AA	245	208	0.21 (0.05-0.69)	0.019	0.59 (0.41-0.84)	0.003	0.24 (0.05-0.77)	0.029	0.59 (0.43-0.81)	0.001
	AG	73	96
	GG	3	12
rs7748720	AA	241	193	0.15 (0.03-0.47)	0.003	0.51 (0.36-0.72)	0.0002	0.18 (0.04-0.55)	0.007	0.51 (0.37-0.70)	0.00003
	AG	75	107
	GG	3	15
rs9295478	GG	72	93	2.08 (1.33-3.27)	0.001	1.46 (1.01-2.10)	0.042	1.83 (1.26-2.66)	0.001	1.44 (1.15-1.81)	0.002
	GA	149	160
	AA	100	63
rs6935599	AA	72	93	2.05 (1.31-3.22)	0.002	1.45 (1.01-2.10)	0.044	1.80 (1.24-2.62)	0.002	1.43 (1.14-1.79)	0.002
	AG	149	160
	GG	99	63
rs7747752	CC	76	96	1.96 (1.25-3.09)	0.004	1.45 (1.01-2.08)	0.042	1.69 (1.16-2.48)	0.006	1.39 (1.11-1.75)	0.004
	CG	153	159
	GG	92	60
rs9350276	AA	188	155	0.46 (0.26-0.81)	0.008	0.67 (0.49-0.92)	0.014	0.52 (0.30-0.90)	0.021	0.70 (0.55-0.89)	0.004
	AG	110	122
	GG	23	39
rs6938256	AA	207	165	0.39 (0.20-0.74)	0.005	0.58 (0.42-0.81)	0.001	0.46 (0.24-0.87)	0.019	0.63 (0.48-0.81)	0.0005
	AG	96	118
	GG	16	30

and indicate that the associations were statistically significant at the 0.20 and 0.05 levels after adjusting for multiple comparisons using the FDR method. ^#ORs were adjusted for maternal age, maternal BMI, parity, and family history of diabetes.