Journal of Diabetes Research

Research Article

Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study

Table 3

Associations of ln-F/E and ln-11-deoxycortisol with prediabetes and T2DM in a male and female.
MaleFemale
Model 1Model 2Model 3Model 1Model 2Model 3
Prediabetes      
Ln-F/E      
Continuous0.91 (0.78-1.07)0.92 (0.78-1.08)0.93 (0.78-1.10)0.88 (0.77-1.01)0.90 (0.78-1.03)0.90 (0.78-1.03)
T1ReferenceReferenceReferenceReferenceReferenceReference
T20.67 (0.46-0.96)0.73 (0.50-1.06)0.71 (0.48-1.06)0.98 (0.72-1.32)1.01 (0.74-1.37)1.07 (0.78-1.47)
T30.97 (0.66-1.43)1.07 (0.83-1.84)1.07 (0.70-1.64)0.97 (0.73-1.30)1.04 (0.77-1.40)1.06 (0.77-1.45)
Ln-11-deoxycortisol      
Continuous0.73 (0.60-0.89)0.75 (0.61-0.92)0.76 (0.61-0.93)0.73 (0.62-0.86)0.74 (0.63-0.87)0.70 (0.59-0.83)
T1ReferenceReferenceReferenceReferenceReferenceReference
T20.69 (0.40-1.19)0.57 (0.32-1.01)0.58 (0.32-1.05)0.43 (0.29-0.64)0.44 (0.29-0.67)0.43 (0.28-0.66)
T30.43 (0.25-0.73)0.40 (0.23-0.70)0.40 (0.22-0.71)0.42 (0.28-0.63)0.42 (0.28-0.65)0.40 (0.26-0.62)
T2DM      
Ln-F/E      
Continuous0.92 (0.81-1.06)0.92 (0.80-1.07)0.88 (0.76-1.03)0.79 (0.69-0.90)0.77 (0.70-0.88)0.72 (0.62-0.83)
T1ReferenceReferenceReferenceReferenceReferenceReference
T20.79 (0.55-1.13)0.90 (0.59-1.39)0.97 (0.61-1.53)0.67 (0.50-0.90)0.67 (0.49-0.93)0.62 (0.44-0.88)
T30.84 (0.58-1.22)1.01 (0.66-1.55)0.86 (0.54-1.36)0.61 (0.45-0.83)0.65 (0.47-0.90)0.56 (0.39-0.80)
Ln-11-deoxycortisol      
Continuous0.97 (0.79-1.19)1.03 (0.82-1.30)1.57 (0.87-2.81)0.86 (0.74-1.01)0.85 (0.72-1.01)0.78 (0.65-0.93)
T1ReferenceReferenceReferenceReferenceReferenceReference
T21.13 (0.64-2.01)1.18 (0.61-2.27)1.23 (0.61-2.48)0.55 (0.37-0.82)0.51 (0.33-0.79)0.48 (0.30-0.77)
T30.88 (0.50-1.57)1.02 (0.53-1.97)1.03 (0.51-2.09)0.58 (0.38-0.88)0.53 (0.34-0.85)0.44 (0.27-0.73)
Data are ORs (95% CI). Abbreviation: ln-: natural log-transformed; F/E: cortisol-to-cortisone ratio; T2DM: type 2 diabetes mellitus; ORs: odds ratios; CI: confidence interval. Model 1: no adjustment; model 2: adjusted for BMI, smoking status, alcohol intake, physical activity, per capita monthly income, educational attainment, and family history of T2DM; model 3: model 2+SBP, TC, TG, HDL-C, and LDL-C. Boldface values: .