Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

Figure 4

Expression of IRS-1 and pSer IRS-1 by immunohistochemistry in a light microscope: (a) IRS-1 in the control group (×400), (b) IRS-1 in the NGT group (×400), (c) IRS-1 in the IGT group (×400), (d) IRS-1 in the DM group (×400), (e) IRS-1 in the DKD group (×400), (f) pSer IRS-1 in the control group (×400), (g) pSer IRS-1 in the NGT group (×400), (h) pSer IRS-1 in the IGT group (×400), (i) pSer IRS-1 in the DM group (×400), and (j) pSer IRS-1 in the DKD group (×400).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)