Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

Table 4

Semiquantitative analysis of IRS-1, pSer IRS-1, megalin, and cubilin in renal tubule and interstitium.

Group	IRS-1	pSer IRS-1	Megalin	Cubilin
Control
NGT
IGT	^ab	^ab	^ab	^ab
DM	^abc	^abc	^abc	^abc
DKD	^abcd	^abcd	^abc	^abc
	0.001	0.001	0.001	0.001

^a vs. the control group. ^b vs. NGT. ^c vs. IGT. ^d vs. DM.