Research Article
In Silico Analysis of Coding/Noncoding SNPs of Human RETN Gene and Characterization of Their Impact on Resistin Stability and Structure
Table 3
Prediction of change in protein stability using I-Mutant2.0 and MUpro.
| | Position | I-Mutant2.0 | MUpro | | DDG value (kcal/mol) | DDG value | SVM | NN (kcal/mol) |
| | I32S | -2.45 (decrease) | -1.490 (decrease) | -0.80 (decrease) | -0.96 (decrease) | | C51Y | -0.89 (decrease) | -0.234 (decrease) | -0.20 (decrease) | -0.69 (decrease) | | G58R | -0.15 (decrease) | -0.95 (decrease) | -0.22 (decrease) | -0.73 (decrease) | | G58E | -1.43 (decrease) | -0.913 (decrease) | 0.23 (increase) | -0.67 (decrease) | | G66R | -1.74 (decrease) | -0.84 (decrease) | 0.48 (increase) | 0.51 (increase) | | C74W | -0.76 (decrease) | -0.69 (decrease) | 0.54 (increase) | 0.85 (increase) | | C78S | -0.63 (decrease) | -1.513 (decrease) | -0.09 (decrease) | 0.87 (increase) | | G79C | -0.89 (decrease) | -0.842 (decrease) | -0.84 (decrease) | -0.38 (decrease) | | D97E | 0.52 (increase) | -0.77 (decrease) | 0.025 (increase) | -0.65 (decrease) | | W98C | -1.14 (decrease) | -0.442 (decrease) | -0.77 (decrease) | -0.92 (decrease) | | W98L | -0.59 (decrease) | 0.16 (increase) | -0.10 (decrease) | 0.691 (increase) | | C103G | -1.05 (decrease) | -1.63 (decrease) | -0.80 (decrease) | 0.547 (increase) | | C104Y | 0.32 (increase) | -1.03 (decrease) | -0.36 (decrease) | -0.80 (decrease) |
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DDG: delta delta G; SVM: support vector machine; NN: neural network.
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