Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Figure 3

The influence of losartan on the hippocampal expression of genes encoding KAT I, KAT II, and KAT III (CCBL1 (kat 1), AADAT (kat 2), and KAT3 (kat 3)) in diabetic rats. Normalized with the reference to Gapdh expression of genes was analyzed with Expression Suite Software v1.0.3 (ThermoFisher Scientific). Data are presented as LogRQ. CTR: nondiabetic, healthy rats receiving vehicle; LOS: nondiabetic rats receiving losartan; DM: animals with streptozotocin- (STZ-) induced diabetes; DM+LOS: diabetic animals treated with losartan for 28 days; DM+INS: diabetic animals treated with insulin for 28 days; DM+INS+LOS: diabetic animals treated with insulin and losartan for 28 days.