HNF1<i>α</i> Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway

<div>HNF1<i>α</i> inhibits FFA-induced steatosis in LO2 cells. (a) Oil Red O staining showed that the number of red granular lipid droplets decreased after upregulating the expression of HNF1<i>α</i> and the number of red granular lipid droplets increased after downregulating the expression of HNF1<i>α</i>. (b–d) Biochemical indicator tests showed that the upregulation of HNF1<i>α</i> expression caused significant decreases in TC, TG, and NEFA content. Downregulation of HNF1<i>α</i> expression led to significantly increased content of TC, TG, and NEFA. 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Journal of Diabetes Research

fig3

Figure 3

Figure 3: HNF1<i>α</i> Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway 

Journal of Diabetes Research

HNF1α Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway

Figure 3