HNF1<i>α</i> Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway

<div>HNF1<i>α</i> inhibits the STAT3 pathway and promotes lipolytic catabolism lipid anabolism. (a) Western blot analysis showed that upregulation of HNF1<i>α</i> expression promoted the expression of SOCS-3, inhibited the phosphorylation of STAT3, downregulated the expression of HNF1<i>α</i>, inhibited the expression of SOCS-3, and promoted the phosphorylation of STAT3. (b) RT-qPCR and western blot showed that upregulation of HNF1<i>α</i> expression inhibited the expression of SREBP-1c, promoted the expression of PPAR<i>α</i>, downregulated the expression of HNF1<i>α</i>, promoted the expression of SREBP-1c, and inhibited the expression of PPAR<i>α</i>. 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Journal of Diabetes Research

fig5

Figure 5

Figure 5: HNF1<i>α</i> Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway 

Journal of Diabetes Research

HNF1α Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway

Figure 5