A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA’s Ability to Inhibit Inflammatory T Cells

Figure 3

Alprazolam augments the ability of GABA to inhibit antigen-specific T cell proliferative responses. Mice were immunized with HEL, and nine days later, their splenic mononuclear cells were assayed in triplicate for proliferative responses to HEL as described in Materials and Methods. Each line represents a molar concentration of alprazolam together with different concentrations of GABA from six mice in two separate experiments. , , and vs. the medium alone. , , and vs. the GABA alone at the same concentration.